Each episode centers on Nuku Nuku's adventures and mishaps in high school, and her relationship to students, the overall series plot centers on the evil Mishima Industries' scheme to dominate the world through its products.
In opposition to this plan are the slightly nutty Kyuusaku Natsume and Nuku Nuku, the android who acts as a companion to his young son. Nuku Nuku's classmates are all eccentrics, Futaba, the class president, is a domineering control-freak, who cannot leave her authority in school. Chieko Shirakaba is the rich snob with the two yes-girls who always take her side. There is a bookworm, a mystic, a scientist, and a pop singer. All of these are true to their descriptions: the mystic is always foretelling doom via tarot cards, spirits, or some other occult technique. The pop singer never says anything except as a song. The bookworm always has her nose in a book. These eccentricities add to the series' humor.